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G6PDD Test

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Glucose-6-Phosphate Dehydrogenase Deficiency (G6PDD) Test

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme defect in humans.G6PD deficiency is widely distributed in tropical and subtropical parts of the world and a conservative estimate is that at least 500 million people have a G6PD deficient gene. In several of these areas, the frequency of a G6PD deficiency gene may be as high as 20% or more. The vast majority of people with G6PD deficiency remain clinically asymptomatic throughout their lifetime. However, all of them have an increased risk of developing neonatal jaundice and a risk of developing acute hemolytic anemia when challenged by a number of oxidative agents used particularly in dental procedures. The most important treatment measure is prevention: Avoidance of the drugs and foods that cause hemolysis. People with G6PD deficiency have problems in metabolizing anti-diabetic medications and should get tested for this gene or check their G6DP enzyme activity using this test.